Pathways to clinical impact

Disease to design

Personalised patient care by mapping disease distribution to device design and selection


3D visualisation and analysis of diseased arteries. Image fusion of intravascular ultrasound and X-Ray angiography

Heart valves

Design of bespoke replacement aortic heart valves for the treatment of aortic stenosis

About Us

Collaborative expertise in computational engineering and interventional cardiology
Improved patient care through design collaboration

Carena Healthcare was formed in 2016 as a result of a longstanding collaboration between Professors Neil Bressloff (University of Southampton) and Nick Curzen (University Hospital Southampton Trust). Over many years they have explored how computational engineering and design tools can be used (i) to simulate interventional cardiology procedures for coronary artery stenting and transcatheter aortic valve implantation (TAVI) and (ii) to optimise cardiac device design and/or procedures, all with the aim of improving outcomes for patients. Carena Healthcare is now perfectly poised to take interventional cardiology device design to a new level, supported by the collaborative expertise in computational engineering and interventional cardiology.

  • Computer modelling

    Patient-specific simulation

  • Device Design

    Heart valves & coronary stents

  • Device selection

    Heart valves & coronary stents

  • Clinical Practice

    Interventional cardiology

Bailey, J., Curzen, N. and Bressloff, N. W., 2017. The impact of imperfect frame deployment and rotational orientation on stress within the prosthetic leaflets during transcatheter aortic valve implantation. J. Biomech.

Ragkousis, G., Curzen, N. and Bressloff, N. W., 2016. Multi-objective optimisation of stent dilation strategy in a patient-specific coronary artery via computational and surrogate modeling. J. Biomech.. 49(2):205-215. Final version at

Bailey, J., Curzen, N. and Bressloff, N. W., 2016. Assessing the impact of including leaflets in the simulation of TAVI deployment in to a patient specific aortic root. Comp. Meth. in Biomech. and Biomed. Eng. 19(7): 733-744. The final publication is available at Taylor & Francis via

Bressloff, N. W., Ragkousis, G. and Curzen, N., 2016. Design optimisation of coronary artery stent systems. Annals. Biomed. Eng. 44(2): 357-367. Final version at Springer

Ragkousis, G., Curzen, N. and Bressloff, N. W., 2015. Computational modelling of multi-folded balloon delivery systems for coronary artery stenting: Insights into patient-specific stent malapposition Annals. Biomed. Eng., 43(8):1786-1802. DOI: 10.1007/s10439-014-1237-8. The final publication is available at Springer via

Pant, S., Limbert, G., Curzen, N. and Bressloff, N. W. , 2011, Multi-objective design optimisation of coronary stents, Biomaterials, 32: 7755-7773. Leading Opinion Paper. Final version at Elsevier

Pant, S., Bressloff, N. W., Forrester, A. I. J. and Curzen, N., 2010, The influence of strut-connectors in stented vessels : A comparison of pulsatile flow through five different coronary stents, Annals. Biomed. Eng., 38(5): 1893-1907. Final version at Springer

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